The link between obesity and cancer


the link between obesity and cancer Changes in intestinal bacterial populations may explain why an obese mouse has greater risk of liver cancer. This shows that the link between obesity and cancer could be explained. The research of the Japanese Foundation for Cancer Research in Tokyo is published this week in Nature .
Cancer Biologist Eiji Hara and his colleagues studied initially how outdated, dying cells can influence the development of cancers. Cells that are irreparably damaged, “senescent” (or literally obsolete), means that they stop dividing and therefore no longer provide new, young cells. Just for senescent cells die, they spit out dust which can cause inflammation and promote the development of cancer.
The researchers studied genetically modified mice whose cells are senescent. They found the mice exposed to a carcinogen, at a dose which ratio is equal to human exposure to air pollution, as an example. The mice were then given a normal or high-fat diet. After three weeks of exposure only five percent of the lean mice developed cancer in their lungs, on the other hand all other obese mice were liver cancer.
The Japanese scientists couldn’t understand these results initially, but when they compared the blood serum of both groups, the researchers found that obese mice have a much higher blood concentration deoxy cholic acid (DCA), a substance which could be resulted in DNA damage and cell aging. DCA is produced by intestinal bacteria that bile acids, which help in the digestion of fat, are converted in to the more harmful DCA. This sort of harmful DCA tend to be then absorbed into the bloodstream and thus ends up in the liver.
The researchers found that the obese mice had much more DCA producing bacteria in their intestines, and that obese mice that were given antibiotics to eradicate the intestinal bacteria developed liver cancer less.


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