new type of malaria vaccine


 U.S. researchers have succeeded with a new type of malaria vaccine. 
Malaria is caused by Plasmodium parasites, which are spreaded by mosquitoes. According to the World Health Organization the disease was  found in about 220 million people in 2010 . Of these, more than 650,000 died, mostly children. Already in the 1970s, scientists discovered that it is possible to be protected against the disease by letting stabbing by mosquitoes that were initially irradiated to weaken malaria parasite. It did, however, but fail to get parasites from mosquitoes and thus treat them sufficiently attenuated but were still active enough that they can be administered as a vaccine. The American scientists now succeeded to took sporozoites from the salivary glands of mosquitoes, an immature stage of the Plasmodium parasite that reaches the stabbing in the blood. After irradiation they injected their vaccine in subjects who then were exposed to mosquitoes. Of the six subjects who received five doses of the vaccine was not infected. Also, six of the nine subjects who received four doses were resistant to the disease. Five of the six non-vaccinated in contrast, were infected – and treated immediately. The new vaccine thus seems to present a different, more advanced candidate, which contain a complete sporozoites. Disadvantage is that the vaccine should be injected, in the field which is more complex than injection into a muscle directly into the blood. The researchers call the results themselves ‘very promising’ but point out that the study still needs to be improved. Subjects with more Furthermore, the question still remains to what extent the vaccine provides protection against various types of parasites and how long the effect lasts.


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